After 2200 km driving a W223 S 500 4matic here are some personal impressions.
Exterior: Was discussed in length here.
Interior: I really like it. Clean, innovative, and luxurious at once.
Going for touch only is weird, because its only “halfway touch”: The buttons are touch sensitive, however you still have to mechanically press it. If you do so you are going to press down the whole control panel which feels kind of strange. Additionally, it is hard to find the right button by not looking at it and without direct haptic feedback.
Touch screen in the center console is nice if you are not driving and perfect for adjust every little detail – and there are a lot. But distracting during driving because you can not control it without looking at it. Additionally, you cannot directly access the different submenus (comfort, navigation, radio, media…). It is nearly always necessary to go back to the main menu and then proceed to the respective submenu (in contrast, using W223s Apple car play gives you that functionality). Voice control is not an appropriate alternative because it only understands 70 – 80% of your commands.
Adjusting the volume by the touch slider? Hmm… The previous roller bar was better.
Driving / Comfort: Driving and comfort with respect to NVH is more or less the same as in the previous model but on a more refined level. In the W222 going higher speed was completely effortless, now they raised that bar for 10 – 15 km/h more.
The R6 is a surprisingly noisy engine especially when started (see the detailed review of Georg Kacher in carmagazine.co.uk).
Suspension at the first drive felt strange: In comfort mode you are experiencing a vertical and horizontal rolling as being on a boat. In Sport mode suspension is stiffer and similar to the Comfort mode of the W222. Now I am used to it, and it feels nice and comfy.
Doors:
In contrast to the W222 doors now cannot be arrested in every position (only three positions). Otherwise, they collapse. Especially in narrow parking slots this is an annoying issue because the door is always slamming at you.
Door handles inside are newly designed and similar to W221, i.e., they are again integrated in the door cladding. If the doors are maximally opened it is nearly impossible to reach the door handle in a convenient way because it´s simply too far away.
Small Burmester Sound system is equal to the W222.
Cost cutting:
No door pins for checking the lock/unlock status.
No nets in the trunk left and right.
Gear shifter and turn indicator feel like low budget versions out of a 3D printer
Small folding, i.e. make up mirrors in the back are gone
Reclinable headrests are gone
Best
sl123