Damn, so they're even taking out some creases on the hood. I love those hard angular double creases on each side of the hood.
IMO, the E not looking like the S is the best thing you can ask from these cars. If you see them together, the E looks a lot more dynamic, sporty, and aggressive than the S, giving it a chance to outshine the S to I'm sure many people who might see the S as more dated or plain next to it. Of course, the S is much more regal, elegant and pure, which in turn benefits the S, who's size alone still give it a more "massive" presence than the E with all its extra creases and design dynamics. Both play off each other great, IMO. Clearly brothers, but with their own charms.
The W211 generation was very homogenized, and I don't think it helped any of them when you saw them together.... was kind of a boring sight. BMW and Audi are ruining the presence of their flagships by making them so close to the smaller cars.
As for interiors, I sat in a '07 W221 the other day, then got back in my E. The S had a very bland color combo while my car has a nice two tone with burl wood, and I liked my cars interior feel and design better. Just felt more modern yet classic and had some more character.
What the E's interior needs most of all isn't a redesign, IMO it's a perfect fit for the hard lined exterior, and it looks very W126 era-ish, it just needs more refined/soft materials. Maybe a bit more coddling. Though, part of its charm is how "German cold" it is. I personally would like more coziness inside.