Now it is more difficult to differentiate between R8 V8 and R8 V10. Even if DSG is a good upgrade, I'd chose the manual transmission, the last manual to use the aluminium grid. Even Ferrari doesn't have that anymore.
I drove an R-Tronic R8 a while and didn't really like it so the switch to S-Tronic will completely transform the car in my opinion, never driven the manual version though I've driven the F430 in manual with the metal gate and though it's got a great feel I didn't rate it that great when driving fast and performing multiple shifts per lap, though to be fare familiarity may improve this opinion.