Does the S class even matter? Europe uses them as fancy taxis. I don’t think the US is buying as many… not sure how China stacks up but aren’t sedans dead?!? Would it REALLY matter how this looks?
Its the pre-eminent luxury car. We can talk about Rolls Royce and Bentley and the like, but those blast into insane realms of unobtainium, meanwhile the S-class remains the benchmark of attainable luxury.
And as Mr Mercedes said, it matters for the brand. Whatever is in the S-class, will trickle down to other cars in 15 years time. Including Mercedes' own.
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As for the question of the interior. I want them to de-emphasise screens. Sure have a big screen, but make it possible to either shut it off easily or hide it away when not in use. Maybe you could have the IWC Schaffhausen Clock and a couple other mechanical dials (compass, altimeter or something) on the trim piece that covers the screen? Or at least integrates if you want those dials to be visible at all times.
Physical controls for HVAC and other essential features like front and rear de-mist/frost, heated/ventilated seats, drive modes etc. The climate/temperature settings should have their own warm colour temperature screens, so the main screen doesn't need to be switched on to show temps, fan speeds etc.
Physical controls for volume, track select (skip, back) and turning the audio system on/off.
Ideally bring back the COMAND dial without the silly touchpad that covered it, so there's a way to interact with the screen without touching it.
Steering wheel with actual f#cking buttons/dials instead. Don't just copy the previous generation one with the blackberry selector, cause that was rubbish. Make a d-pad or clicky, depressible joystick - ideally the latter, for tactility.
Also, while the previous gen one had great tactile buttons for returning home, cruise control, the amazing volume scroll wheel, and those are good to carry over, for heaven's sake why didn't the steering wheel controls have skip-track, pause or go back one track? You had to swipe on the blackberry dials whilst on the media menu on the track - and that didn't work on Android Auto/Apple Carplay. Insane oversight. Of literally anything a driver might want to do while not having to look at the f#cking screen, its change tracks while listening to music.
Finally, get rid of ALL piano black plastic. It looks nice for 10 seconds when new, then it immediately magnets dust, and gets scratched into oblivion. If you want shiny black surfaces, at least use ceramic or some kind of hard coating that won't get scratched by keys, fingernails or whatever. Ideally though, no gloss surfacing, except for the odd accent.