And I'm very happy to hear you say that about the CLS (and so is my Bank account!

).
Of course, cars will have their problems, and the F10 is by no means an "avoid it" case, but it has had some more drastic and continuous problems than the W212. I've gotten this info from the best and only sources possible (Internet Owners Forums, and publications, etc.). F10 owners will usually say "Do not buy pre-September '10 builds", which says that BMW had quite a bit of "fixing" to do, right off the bat.
The jerky takeoff is an annoyance that BMW hasn't yet really taken care of, and the Fuel Pumps are still in question (and still posing problems), and there are quite a few issues reported by numerous owners, more problematic than any of the little things that you'll hear W212 owners complain about.
Anyway, to be fair, the F10 is more technologically advanced than the W212, and it uses newer drivetrains (for the most part at least) so there's more R&D to be done. M-B had to make the W212 a "statement", all the way from the overly-confident and strong speaking design, to the drivetrain carry-overs, etc. since they could not afford a fiasco like the W211 launch.
It reminds me of the 80's era actually, when M-B was a bit more simple, but focused on reliability, and BMW were more advanced in ways, but weren't as long-term dependable. However, with M-B's new and more complex drivetrains about to come out, some of this could possibly change.